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NAPLEX – North American Pharmacist Licensure Examination

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Showing 1–3 of 10 questions

Question 1

Octreotide 50mcg/hr is ordered for a patient with esophageal varices, nurses prepared by mixing 1ml of concentration 0.5mg/ml of octreotide in 50mls NS. What rate should the bag be infused?

Select an option, then click Submit answer.

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    50ml/hr
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    5ml/hr
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    5ml/min
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    0.5ml/min
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    7ml/hr
Question 2

A 72-year-old woman suffers from a major depressive episode. She has a history of coronary artery disease, atrial fibrillation on anticoagulation therapy, sick sinus syndrome, glaucoma, and chronic obstructive pulmonary disease.

Which of the following medications is most appropriate for the treatment of her depression?

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  • ○

    Amitriptyline
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    Nortriptyline
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    Doxepin
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    Fluvoxamine
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    Escitalopram
Question 3

Which of the following represents the major route of metabolism for acetaminophen?

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    Glucuronidation
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    Sulfation
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    Cytochrome P-450 oxidation
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    Direct renal excretion
    The major route is glucuronidation catalyzed by UDP-glucuronyl transferase in the liver. Sulfation is the next most common route and is the target mechanism for NAC therapy. Oxidation by cytochrome P-450 results in the formation of N-acetyl-p-benzoquinone imine, which is responsible for the hepatic necrosis caused by acetaminophen overdose. Direct renal excretion represents approximately 5% of the metabolism of acetaminophen. Plasma metabolism of acetaminophen does not generally occur.
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    Plasma breakdown